Embryotoxicity of ozonated diclofenac, carbamazepine, and oxazepam in zebrafish (Danio rerio)
نویسندگان
چکیده
منابع مشابه
Danio Rerio, the Zebrafish
The zebrafish has long been a favourite model for the study of vertebrate development. Here we provide an overview of the current state of knowledge and resources for the study of this fish, with comments on the future direction of zebrafish genomics from Professor Mark Fishman and Dr Stephen Wilson.
متن کاملBIOLOGY OF ZEBRAFISH, Danio rerio
Zebrafish, Danio rerio (Hamilton), is one of the most important vertebrate model organism in genetics, developmental biology, neurophysiology and biomedicine (Rubinstein, 2003; Amsterdam and Hopkins, 2006). It is a small, robust fish, so large numbers can be kept easily and cheaply in the laboratory, where it breeds all year round. Development is rapid, with precursors to all major organs devel...
متن کاملAssessment of diclofenac LC50 reference values in juvenile and embryonic stages of the zebrafish (Danio rerio).
The aim of the study was to compare the acute toxicity of diclofenac to juvenile and embryonic stages of the zebrafish (Danio rerio). Acute toxicity tests were performed on the aquarium fish Danio rerio, which is one of the model organisms most commonly used in toxicity testing. The tests were performed using a semi-static method according to OECD guideline No. 203 (Fish, acute toxicity test). ...
متن کاملDevelopmental Toxicity of Diclofenac and Elucidation of Gene Regulation in zebrafish (Danio rerio)
Environmental pollution by emerging contaminants, e.g. pharmaceuticals, has become a matter of widespread concern in recent years. We investigated the membrane transport of diclofenac and its toxic effects on gene expression and the development of zebrafish embryos. The association of diclofenac with the embryos conformed to the general partition model at low concentration, the partition coeffi...
متن کاملInhibitory Avoidance Learning in Zebrafish (Danio rerio)
The zebrafish (Danio rerio) is increasingly being used as model in behavioural [1,2], neurobiological and genetic research [3]. Underlying reasons are high genetic homology to humans [4] and the many advantages over the use of rodents, such as low cost, easy handling, short reproduction cycle and high fecundity. Furthermore, its genome [5], transcriptome [6] and proteome [7] are well described,...
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ژورنال
عنوان ژورنال: Chemosphere
سال: 2019
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2019.03.034